the Gingras Laboratory

The Lunenfeld-Tanenbaum Research Institute

Welcome to the Gingras Lab!

We are a signal transduction, systems biology and proteomics lab located in the Lunenfeld-Tanenbaum Research Institute in Toronto.

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases that regulate the response of cells to environmental stimuli. Importantly, misregulation of this process has been implicated in numerous diseases, including cancer and diabetes. We are particularly interested in understanding how phosphatases respond to different environmental cues and how they recognize their substrates. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to shed light on this important enzyme family. This being said, we also have other fun projects, which you can see under the Research tab.

We also develop technologies and software tools for proteomics, primarily for the analysis of protein-protein interactions. These are listed under the Resources tab. Have a look at our experimental protocols and available cloning vectors. Please also see our dedicated website for the distribution of ProHits, a Laboratory Information Management System for AP-MS experiments. Explore the Contaminant Repository for Affinity Purification (or CRAPome), a resource to help biologists making sense of their interaction data, and navigate our own Interaction Repository.

Recent funding from Genome Canada enabled the creation at the Lunenfeld-Tanenbaum of the Network Biology Collaborative Centre (NBCC) who is now accepting samples in both the SMART screening and proteomics facilities.

Rewiring the BET interactome 2018
See our manuscript by Lambert, Picaud et al. that reports the effects of the drug JQ1 on the interactome of the BET family of bromodomains online at Molecular Cell. A great collaboration between the Gingras and Filippakopoulos labs, with help from many colleagues across the world. More ...

Computational postdoc positions available 2018
The Gingras and Rost labs are looking for postdoctoral fellows in Computational Proteomics to lead the development of the next generation of tools for Data Independent Analysis. Apply here. More ...

Become my newest colleague! 2018
The Lunenfeld is recruiting 3 new PIs in the Fall. The Molecular, Cell and Systems Biology position is now open - cross-appointment at the University of Toronto! Apply here. See all open positions here. More ...

Lentiviral toolbox: BioID across cell types! 2018
Payman Samavarchi-Tehrani and colleagues report in Molecular and Cellular Proteomics a collection of lentiviral vectors to enable proximity-dependent biotinylation across cell types. More ...

Cytosolic RNA granules and bodies out in Mol Cell 2018
Congratulations to all co-authors and to PDF Jiyoung Youn, profiled at Molecular Cell for her paper selected as Featured Article (free). Also see the nice Preview by Simon Alberti. More ...

We are growing! Welcome to our new students! 2017
The rotation students were great this year: very happy to recruit Kento Abe, Julia Kitaygorodsky, Shimon Rosenthal (co-supervised with Ian Scott) and Francesco Zangari to the lab. More ...

ProHits CRAPome NBCC ProHits SAINT
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