the Gingras Laboratory

The Lunenfeld-Tanenbaum Research Institute

Welcome to the Gingras Lab!

We are a signal transduction, systems biology and proteomics lab located in the Lunenfeld-Tanenbaum Research Institute in Toronto.

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases that regulate the response of cells to environmental stimuli. Importantly, misregulation of this process has been implicated in numerous diseases, including cancer and diabetes. We are particularly interested in understanding how phosphatases respond to different environmental cues and how they recognize their substrates. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to shed light on this important enzyme family. This being said, we also have other fun projects, which you can see under the Research tab.

We also develop technologies and software tools for proteomics, primarily for the analysis of protein-protein interactions. These are listed under the Resources tab. Have a look at our experimental protocols and available cloning vectors. Please also see our dedicated website for the distribution of ProHits, a Laboratory Information Management System for AP-MS experiments. Explore the Contaminant Repository for Affinity Purification (or CRAPome), a resource to help biologists making sense of their interaction data, and navigate our own Interaction Repository.

Recent funding from Genome Canada enabled the creation at the Lunenfeld-Tanenbaum of the Network Biology Collaborative Centre (NBCC) who is now accepting samples in both the SMART screening and proteomics facilities.

Have long gene lists to annotate? Try this! 2019
James Knight, with input from Payman Samavarchi-Tehrani, has created a useful Chrome plug-in to rapidly retrieve information on gene products directly on the browser page. Try it here. More ...

Alpha-test our new visualization tool 2019
James Knight has been redesigning the ProHits-viz series of visualization tools to enable better handling of large files. Alpha-test it here. More ...

Rewiring the BET interactome 2018
See our manuscript by Lambert, Picaud et al. that reports the effects of the drug JQ1 on the interactome of the BET family of bromodomains online at Molecular Cell. A great collaboration between the Gingras and Filippakopoulos labs, with help from many colleagues across the world. More ...

Computational postdoc positions available 2018
The Gingras and Rost labs are looking for postdoctoral fellows in Computational Proteomics to lead the development of the next generation of tools for Data Independent Analysis. Apply here. More ...

Become my newest colleague! 2018
The Lunenfeld is recruiting 3 new PIs in the Fall. The Molecular, Cell and Systems Biology position is now open - cross-appointment at the University of Toronto! Apply here. See all open positions here. More ...

Lentiviral toolbox: BioID across cell types! 2018
Payman Samavarchi-Tehrani and colleagues report in Molecular and Cellular Proteomics a collection of lentiviral vectors to enable proximity-dependent biotinylation across cell types. More ...

ProHits CRAPome NBCC ProHits SAINT
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