the Gingras Laboratory

The Lunenfeld-Tanenbaum Research Institute

Welcome to the Gingras Lab!

We are a signal transduction, systems biology and proteomics lab located in the Lunenfeld-Tanenbaum Research Institute at the Mount Sinai Hospital in Toronto.

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases that regulate the response of cells to environmental stimuli. Importantly, misregulation of this process has been implicated in numerous diseases, including cancer and diabetes. We are particularly interested in understanding how phosphatases respond to different environmental cues and how they recognize their substrates. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to shed light on this important enzyme family. This being said, we also have other fun projects, which you can see under the Research tab.

We also develop technologies and software tools for proteomics, primarily for the analysis of protein-protein interactions. These are listed under the Resources tab. Have a look at our experimental protocols and available cloning vectors. Please also see our dedicated website for the distribution of ProHits, a Laboratory Information Management System for AP-MS experiments. Explore the Contaminant Repository for Affinity Purification (or CRAPome), a resource to help biologists making sense of their interaction data, and navigate our own Interaction Repository.


Cell paper by the Gingras and Lindquist labs 2014
Taipale et al. report a quantitative chaperone interaction network that reveals the architecture of cellular protein homeostasis pathways. More ...

Funding from NSERC awarded 2013
We recently obtained a NSERC Discovery grant and an Accelerator Supplement to study the specificity in RNA storage and degradation associated to p bodies and stress granules. More ...

Chris Go receives doctoral award 2014
Congrats to Chris Go on getting a competitive Frederick Banting and Charles Best Canada Graduate Scholarship. More ...

Stopping the Hippos 2013
Hundreds of new connections and mechanisms of phospho-recognition in the Hippo pathway published by Amber Couzens et al. in Science Signaling - also see accompanying perspective by Eric Weiss. More ...

AP-SWATH paper in Nature Methods 2013
In a collaboration with AB SCIEX and the support of Venture Sinai, Lambert et al. present AP-SWATH which rapidly maps differential interactomes. More ...

Older news
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