the Gingras Laboratory

The Lunenfeld-Tanenbaum Research Institute

Welcome to the Gingras Lab!

We are a signal transduction, systems biology and proteomics lab located in the Lunenfeld-Tanenbaum Research Institute at the Mount Sinai Hospital in Toronto.

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases that regulate the response of cells to environmental stimuli. Importantly, misregulation of this process has been implicated in numerous diseases, including cancer and diabetes. We are particularly interested in understanding how phosphatases respond to different environmental cues and how they recognize their substrates. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to shed light on this important enzyme family. This being said, we also have other fun projects, which you can see under the Research tab.

We also develop technologies and software tools for proteomics, primarily for the analysis of protein-protein interactions. These are listed under the Resources tab. Have a look at our experimental protocols and available cloning vectors. Please also see our dedicated website for the distribution of ProHits, a Laboratory Information Management System for AP-MS experiments. Explore the Contaminant Repository for Affinity Purification (or CRAPome), a resource to help biologists making sense of their interaction data, and navigate our own Interaction Repository.

Recent funding from Genome Canada enabled the creation at the Lunenfeld-Tanenbaum of the Network Biology Collaborative Centre (NBCC) who is now accepting samples in both the SMART screening and proteomics facilities.


MSPLIT-DIA paper is out in Nature Methods 2015
In a collaboration with Nuno Bandeira, UCSD, we are reporting in Nature Methods a new spectral matching approach for peptide identification from DIA: this will be incorporated in the next ProHits release. More ...

Thank you, Cancer Research Society! 2015
Our lab receives 2 year grant from the Cancer Research Society. We thank the supporters and volunteers of the CRS for all their efforts! More ...

JP Lambert awarded CRS career transition award 2015
Jean-Philippe is awarded a prestigious Scholarship for the Next Generation of Scientists from the Cancer Research Society! More ...

Association of E4orf4 with two major phosphatases 2015
In collaboration with the Branton lab (McGill), MSc student Yiwang Zhou uncovers new mechanisms of signaling regulation by Adenovirus E4orf4: E4orf4 regulates Hippo signaling though PP1 and PP2A. More ...

A Parkinson Society of Canada fellowship to Geoff! 2015
Geoff Hesketh, PDF, receives the prestigious award for his mass spectrometry based characterization of trafficking proteins implicated in Parkinson disease pathogenesis More ...

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