the Gingras Laboratory

The Lunenfeld-Tanenbaum Research Institute

Welcome to the Gingras Lab!

We are a signal transduction, systems biology and proteomics lab located in the Lunenfeld-Tanenbaum Research Institute at the Mount Sinai Hospital in Toronto.

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases that regulate the response of cells to environmental stimuli. Importantly, misregulation of this process has been implicated in numerous diseases, including cancer and diabetes. We are particularly interested in understanding how phosphatases respond to different environmental cues and how they recognize their substrates. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to shed light on this important enzyme family. This being said, we also have other fun projects, which you can see under the Research tab.

We also develop technologies and software tools for proteomics, primarily for the analysis of protein-protein interactions. These are listed under the Resources tab. Have a look at our experimental protocols and available cloning vectors. Please also see our dedicated website for the distribution of ProHits, a Laboratory Information Management System for AP-MS experiments. Explore the Contaminant Repository for Affinity Purification (or CRAPome), a resource to help biologists making sense of their interaction data, and navigate our own Interaction Repository.


Lap-Chee Tsui Publication award to Amber Couzens 2014
Amber Couzens, PDF in our lab, is awarded the prestigious Lap-Chee Tsui publication award for her publication "Protein Interaction Network of the Mammalian Hippo Pathway Reveals Mechanisms of Kinase-Phosphatase Interactions" More ...

Data visualization tool published 2014
James Knight and colleagues publish a web tool for visualization of interaction proteomics data More ...

How to score true interactions in BioID experiment 2014
JP Lambert and colleagues publish in J Proteomics a thorough analysis of background subtraction in BioID experiments and perform a side-by-side comparison of BioID and standard AP-MS for chromatin-associated proteins. More ...

Cell paper by the Gingras and Lindquist labs 2014
Taipale et al. report a quantitative chaperone interaction network that reveals the architecture of cellular protein homeostasis pathways. More ...

Funding from NSERC awarded 2013
We recently obtained a NSERC Discovery grant and an Accelerator Supplement to study the specificity in RNA storage and degradation associated to p bodies and stress granules. More ...

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