the Gingras Laboratory

The Lunenfeld-Tanenbaum Research Institute

Welcome to the Gingras Lab!

We are a signal transduction, systems biology and proteomics lab located in the Lunenfeld-Tanenbaum Research Institute at the Mount Sinai Hospital in Toronto.

Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases that regulate the response of cells to environmental stimuli. Importantly, misregulation of this process has been implicated in numerous diseases, including cancer and diabetes. We are particularly interested in understanding how phosphatases respond to different environmental cues and how they recognize their substrates. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to shed light on this important enzyme family. This being said, we also have other fun projects, which you can see under the Research tab.

We also develop technologies and software tools for proteomics, primarily for the analysis of protein-protein interactions. These are listed under the Resources tab. Have a look at our experimental protocols and available cloning vectors. Please also see our dedicated website for the distribution of ProHits, a Laboratory Information Management System for AP-MS experiments. Explore the Contaminant Repository for Affinity Purification (or CRAPome), a resource to help biologists making sense of their interaction data, and navigate our own Interaction Repository.


MS technician position open 2015
Interested in developing cutting-edge proteomics technologies? We have a full time mass spectrometry technician position available in the group. Apply here. More ...

Network Biology Collaborative Centre is a GIN node 2015
New Funding from Genome Canada for the SMART and proteomics facilities at LTRI. The NBCC team led by Jeff Wrana and Anne-Claude Gingras becomes a Genomics Innovation network node. More ...

Worm CCM3 regulates excretory canal 2015
Ben Lant publishes new research in Nature Communications; work funded by joint CIHR to Drs. Derry and Gingras. More ...

Non-enzymatic role for myotubularins in cell cycle 2015
Nicole St-Denis et al. report that MTMR3&4 control abscission via interactions with PLK1 and CEP55. More ...

DIA-Umpire: a new way to look at SWATH data 2015
A collaboration Gingras/Nesvizhskii leads to the development of a complete informatics pipeline for the analysis of DIA/SWATH data (publication by Tsou et al. in Nature Methods). More ...

Older news
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