Welcome to the Gingras Lab!
We are a signal transduction, systems biology and proteomics lab located in the Lunenfeld-Tanenbaum Research Institute in Toronto.
Reversible protein phosphorylation is mediated by a network of protein kinases and phosphatases that regulate the response of cells to environmental stimuli. Importantly, misregulation of this process has been implicated in numerous diseases, including cancer and diabetes. We are particularly interested in understanding how phosphatases respond to different environmental cues and how they recognize their substrates. We are applying quantitative proteomics approaches, as well as an array of biochemical and cell biology techniques, to shed light on this important enzyme family. This being said, we also have other fun projects, which you can see under the Research tab.
We also develop technologies and software tools for proteomics, primarily for the analysis of protein-protein interactions. These are listed under the Resources tab. Have a look at our experimental protocols and available cloning vectors. Please also see our dedicated website for the distribution of ProHits, a Laboratory Information Management System for AP-MS experiments. Explore the Contaminant Repository for Affinity Purification (or CRAPome), a resource to help biologists making sense of their interaction data, and navigate our own Interaction Repository.
Recent funding from Genome Canada enabled the creation at the Lunenfeld-Tanenbaum of the Network Biology Collaborative Centre (NBCC) who is now accepting samples in both the SMART screening and proteomics facilities.
RECENT NEWS & UPDATES
Cytosolic RNA granules and bodies out in Mol Cell
Congratulations to all co-authors and to PDF Jiyoung Youn, profiled at Molecular Cell for her paper selected as Featured Article (free). Also see the nice Preview by Simon Alberti. More ...
We are growing! Welcome to our new students!
The rotation students were great this year: very happy to recruit Kento Abe, Julia Kitaygorodsky, Shimon Rosenthal (co-supervised with Ian Scott) and Francesco Zangari to the lab. More ...
ProHits-Viz paper is out at Nature Methods
Knight et al. publishes webtool to improve visualization of protein interaction data. Click for "read-only version". More ...
Congrats to our students!
Chris Go and Jonathan Roth are each awarded an Ontario Graduate Scholarship while Benjamin Piette receives a FRQNT from the Quebec government. More ...
Papers delineate MOB1 role in Hippo signaling
Amber Couzens, Shawn Xiong and collaborators used proteomics and structural and biophysical studies to uncover the function of MOB1 in the regulation of the Hippo signaling pathway. See both papers at Mol Cell Proteomics. More ...
Fresh off the press: phosphatases in mitosis
St-Denis et al. report in this issue of Cell Reports the identification of phosphatases implicated in mitosis, and the elucidation of their interactomes.